A Short Review on Beneficial Effects of Selenium on Human Health

Dr. Prosenjt Ghosh
Assistant Professor and HOD, Department of Zoology, Government General Degree College, Kaliganj,
Debagram, Nadia, West Bengal, India
OrchideID Icon https://orcid.org/0009-0009-9153-3139

Published online:30 June, 2024

DOI: https://doi.org/10.52756/lbsopf.2024.e02.013

Keywords: Selenium, Cancer, antioxidant, cardiovascular

Abstract:

The trace element Selenium (Se) is an essential micronutrient for humans and animals. The beneficial effects of Se range from maintenance of metabolic processes, bone stability, immune and endocrine system, helping in reproduction to prevention of various diseases including cancer, brain disorders, asthma etc. Meat, fish and dairy products are considered as best sources of dietary Se. It is an important constituent of two amino acids: selenocysteine and selenomethionine. These two amino acids help to form several essential enzymes in human like thioredoxin reductases, glutathione peroxidases, iodothyronine deionidases and selenoproteins such as selenoprotein O, selenoprotein P or selenoprotein R. Deficiency of Se results in the development of many serious health effects in humans including Keshan disease. So, studies on various aspects of Se have become topic of interest amongst researchers.

References:

  • Acharya, C.K., Das, B., Madhu, N.R., Sau, S., Manna De, M., & Sarkar, B. (2023). A Comprehensive Pharmacological Appraisal of Indian Traditional Medicinal Plants with Anti-diabetic Potential. Springer Nature Singapore Pte Ltd., Advances in Diabetes Research and Management, pp. 163–193, Online ISBN-978-981-19-0027-3. https://doi.org/10.1007/978-981-19-0027-3_8
  • Ago, T., & Sadoshima, J. (2006). Thioredoxin and ventricular remodeling. J. Mol. Cell Cardiol., 41(5), 762-73.
  • Bano, I., Malhi, M., Khatri, P., Soomro, SA., Sajjad, H., Leghari, A., et al. (2019) Effect of dietary selenium yeast supplementation on morphology and antioxidant status in testes of young goat. Pak J. Zool., 51, 979–988.
  • Basini, G., &Tamanini, C. (2000). Selenium stimulates estradiol production in bovine granulosa cells: possible involvement of nitric oxide. Domest Anim Endocrin.,18(1), 1-17.
  • Bellinger, FP., Raman, AV., Reeves, MA., & Berry, MJ. (2009). Regulation and function of selenoproteins in human disease. Biochem J., 422(1), 11-22.
  • Benstoem, C., Goetzenich, A., Kraemer, S., Borosch, S., Manzanares, W., Hardy, G., & Stoppe, C. (2015). Selenium and its supplementation in cardiovascular disease – what do we know? Nutrients., 7(5), 3094-3118.
  • Beukhof, CM., Medici, M., van den Beld, AW., Hollenbach, B., Hoeg, A., Visser, WE., de Herder, WW., Visser, TJ., Schomburg, L., & Peeters, RP. (2016). Selenium status is positively associated with bone mineral density in healthy aging European men. PLOS One., 11(4), e0152748.
  • Biswas, T., Behera, B. K., & Madhu, N.R. (2023). Technology in the Management of Type 1 and Type 2 Diabetes Mellitus: Recent Status and Future Prospects. 26 pages, Springer Nature Singapore Pte Ltd., Advances in Diabetes Research and Management. pp. 111–136. Online ISBN-978-981-19-0027-3. https://doi.org/10.1007/978-981-19-0027-3_6
  • Bleys, J., Navas-Acien, A., & Gualla, E. (2007). Serum selenium and diabetes in U.S. adults. Diabetes Care., 30(4), 829-834.
  • Castaño, A., Ayala, A., Rodríguez-Gómez, JA., Herrera, AJ., Cano, J., & Machado A. (1997). Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat. Neurochem Int., 30(6), 549-555.
  • Chen, N., Zhao, C., & Zhang T. (2021). Selenium transformation and selenium rich foods. Food Biosci., 40, 100875.
  • Dhingra, S., & Bansal, MP. (2006). Attenuation of LDL receptor gene expression by selenium deficiency during hypercholesterolemia. Mol. Cell Biochem., 282(1-2), 75-82.
  • Dominiak, A., Wilkaniec, A., Wroczyński, P., & Adamczyk, A. (2016). Selenium in the therapy of neurological diseases. Where is it going? Curr Neuropharmacol., 4(3), 282-299.
  • Eroglu, C., Unal, D., Cetin, A., Orhan, O., Sivgin, S., & Oztürk A. (2012). Effect of serum selenium levels on radiotherapyas related toxicity in patients undergoing radiotherapy for head and neck cancer. Anticancer Res., 32(8), 3587-3590.
  • Fernandes, AP., & Gandin, V. (2015). Selenium compounds as therapeutic agents in cancer. Biochim Biophys Acta., 1850(8), 1642-1660.
  • Fontenelle, LC., Feitosa, MM., Morais, JBS., Severo, JS., Freitas, TECD., Beserra, JB., Henriques, GS., & Marreiro, DN. (2018). The role of selenium in insulin resistance. Braz J Pharm Sci., 54(1).
  • Gandin, V., Khalkar, P., Braude, J., & Fernandes AP. (2018). Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment. Free Rad Biol Med., 1(127), 80-97.
  • Gharipour, M., Sadeghi, M., Behmanesh, M., Salehi, M., Nezafati, P., &Gharipour, A. (2017). Selenium homeostasis and clustering of cardiovascular risk factors: a systematic review. Acta Biomed., 88(3), 263-270.
  • Hadrup, N., & Ravn-Haren, G. (2020). Acute human toxicity and mortality after selenium ingestion: a review. J. Trace Elem Med Biol., 58, 126435.
  • Hariharan, S., & Dharmaraj, S. (2020). Selenium and selenoproteins: it’s role in regulation of inflammation. Inflammopharmacology., 28(3), 667-695.
  • Hu, Z., Cheng, Y., Suzuki, N., Guo, X., Xiong, H., & Ogra, Y. (2018). Speciation of selenium in brown rice fertilized with selenite and effects of selenium fertilization on rice proteins. Int J Mol Sci., 19(11), 3494.
  • Ibrahim SA., Kerkadi A., & Agouni A. (2019). Selenium and health: an update on the situation in the Middle East and North Africa. Nutrients., 11(7)1457.
  • Jenkins, DJ., Kitts, D., Giovannucci, EL., Sahye-Pudaruth, S., Paquette, M., Blanco, MS., Patel, D., Kavanagh, M., Tsirakis, T., Kendall CWC., Pichika, SC., & Sievenpiper, JL. (2020). Selenium, antioxidants, cardiovascular disease, and all cause mortality: a systematic review andmeta-analysis of randomized controlled trials. Am J Clin Nutr., 112(6), 1642-1652.
  • KieliszekM. (2019). Selenium-fascinating microelement, properties and sources in food. Molecules., 24(7), 1298.
  • Kieliszek M. & Bano I. (2022). Selenium as an important factor in various disease states – a review. EXCLI Journal., 21, 948-966.
  • Kieliszek, M., & Błażejak, S. (2013). Selenium: significance, and outlook for supplementation. Nutrition., 29(5), 713–718.
  • Kieliszek, M., & Błażejak, S. (2016). Current knowledge on the importance of selenium in food for living organisms: a review. The Molecules., 21(5), 609.
  • Kieliszek, M., Lipinski, B., & Błazejak, S. (2017). Application of sodium selenite in the prevention and treatment of cancers. Cells., 6(4), 39.
  • Kim, J., Chung, H.S., Choi, M.K., Roh, Y.K., Yoo, H.., Park, J.., Kim, D.S., Yu, J.M., & Moon, S. (2019). Association between serum selenium level and the presence of diabetes mellitus: a meta-analysis of observational studies. Diabetes Metab J., 43(4), 447-460.
  • Kryukov, GV., Castellano, S., Novoselov, SV., Lobanov, AV., Zehtab, O., Guigo, R., & Gladyshev, NV. (2003). Characterization of mammalian selenoproteomes. Science, 300(5624), 1439-1443.
  • Kuria, A., Tian, H., Li, M., Wang, Y., Aaseth, JO., Zang, J., & Cao, Y. (2021). Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis. Crit Rev Food Sci Nutr., 61(21), 3616-3625.
  • Lenz, M., & Lens, PN. (2009). The essential toxin: the changing perception of selenium in environmental sciences. Sci Total Environ., 407(12), 3620-3633.
  • Loef, M., Schrauzer, GN., & Walach, H. (2011). Selenium and Alzheimer’s disease: a systematic review. J Alzheimer’s Dis. 26(1), 81-104.
  • Madhu, N.R., Sarkar, B., Roychoudhury, S., Behera, B.K. (2022). Melatonin Induced in Cancer as a Frame of Zebrafish Model. © Springer Nature Singapore Pte Ltd. 2022, S. Pathak et al. (eds.), Handbook of Animal Models and its Uses in Cancer Research, pp. 1-18. ISBN: 978-981-19-1282-5 https://doi.org/10.1007/978-981-19-1282-5_61-1
  • Madhu, N.R., Sarkar, B., Biswas, P., Roychoudhury, S., Behera, B.K., & Acharya, C.K. (2023). Therapeutic potential of melatonin in glioblastoma: Current knowledge and future prospects. Biomarkers in Cancer Detection and Monitoring of Therapeutics, Volume-2. Elsevier Inc., pp. 371-386. ISBN 978-0-323-95114-2. https://doi.org/10.1016/B978-0-323-95114-2.00002-9
  • Maulik, N., & Das, DK. (2008). Emerging potential of thioredoxin and thioredoxin interacting proteins in various disease conditions. Biochim Biophys Acta., 1780(11), 1368-1382.
  • Michelle, RAA., Starling, ALP., Kanufre, VC., Soares, RDL., de C Norton, R., Aguiar, MJB., & N Januario, JN. (2012). Selenium intake and nutritional status of children with phenylketonuria in Minas Gerais. Brazil.J Pediatr (Rio J)., 88(5), 396-400.
  • Misra, S., Boylan, M., Selvam, A., Spallholz, JE., & Björnstedt M. (2015). Redox-active selenium compounds—from toxicity and cell death to cancer treatment. Nutrients., 7(5), 3536-3556.
  • Mix, H., Lobanov, AV., & Gladyshev, VN. (2007). SECIS elements in the coding regions of selenoproteins transcripts are functional in higher eukaryotes. Nucleic Acids Res., 35(2), 414-423.
  • Mojadadi, A., Au, A., Salah, W., Witting, P., & Ahmad G. (2021). Role for selenium in metabolic homeostasis and human reproduction. Nutrients., 13(9), 3256.Rayman, MP. (2008). Food chain selenium and human health: emphasis on intake. Br J Nutr., 100(2), 254–268.
  • Razaghi, A., Poorebrahim, M., Sarhan, D., & Björnstedt (2021). M. Selenium stimulates the antitumour immunity: Insights to future research. Eur J Cancer., 155, 256–267. Roman, M., Jitaru, P., & Barbante C. (2014). Selenium biochemistry and its role for human health. Metallomics, 6(1), 25-54.
  • Roy, R., Chakraborty, A., Jana, K., Sarkar, B., Biswas, P., & Madhu, N.R. (2023). The Broader Aspects of Treating Diabetes with the Application of Nanobiotechnology. Springer Nature Singapore Pte Ltd., Advances in Diabetes Research and Management, pp. 137–162, Online ISBN-978-981-19-0027-3, https://doi.org/10.1007/978-981-19-0027-3_7
  • Sarkar, S., Sadhu, S., Roy, R., Tarafdar, S., Mukherjee, N., Sil, M., Goswami, A., & Madhu, N.R. (2023). Contemporary Drifts in Diabetes Management. Int. J. App. Pharm., 15(2), 1-9. https://doi.org/10.22159/ijap.2023v15i2.46792
  • Stranges, S., Marshall, JR., Natarajan, R., Donahue, RP., Trevisan, M., & Combs, GF. (2007). Annals of internal medicine article effects of long term selenium supplementation on the incidence of type 2 diabetes. Ann Intern Med., 147(4), 217-23.
  • Tapiero, H., Townsend, DM., & Tew, KD. (2003). The antioxidant role of selenium and seleno-compounds. Biomed Pharm., 57(3-4), 134-144.
  • Sur, T., Das, A., Bashar, S., Tarafdar, S., Sarkar, B., & Madhu, N.R. (2023). Biochemical Assay for Measuring Diabetes Mellitus. Springer Nature Singapore Pte Ltd., Advances in Diabetes Research and Management, pp. 1–20, Online ISBN-978-981-19-0027-3, https://doi.org/10.1007/978-981-19-0027-3_1
  • Thiry, C., Ruttens, A., De Temmerman L., Schneider, YJ., & Pussemier L. (2012). Current knowledge in species-related bioavailability of selenium in food. Food Chem., 130(4), 767–784.
  • Thomson, CD. (2004). Assessment of requirements for selenium and adequacy of selenium status: a review. Eur J. Clin. Nutr., 58(3), 391-402.
  • Tinggi, U. (2008). Selenium: its role as antioxidant in human health. Environ Health Prev Med., 13(2), 102-108.
  • Toulis, KA., Anastasilakis, AD., Tzellos, TG., Goulis, DG., & Kouvelas, D. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Thyroid, 20(10), 1163-1173.
  • Tsuji, PA., Santesmasses, D., Lee, BJ., Gladyshev, VN., & Hatfield, DL. (2021). Historical roles of selenium and selenoproteins in health and development: the good, the bad and the ugly. Int J. Mol. Sci., 23(1), 5.
  • Ventura, M., Melo, M., & Carrilho, F. (2017). Selenium and Thyroid Disease: From Pathophysiology to Treatment. Int J Endocrinol., 2017, 1297658.
  • Wallenberg, M., Misra, S., & Björnstedt, M. (2014). Selenium cytotoxicity in cancer. Basic Clin Pharmacol Toxicol., 114(5), 377-386.
  • Wang, Y., Rijntjes, E., Wu, Q., Lv, H., Gao, C., Shi, B., & Schomburg, L. (2020). Selenium deficiency is linearly associated with hypoglycemia in healthy adults. Redox Biol., 37, 101709.
  • Wenstrup, D., Ehman, WD., & Markesbery, WR. (1990). Trace element imbalances in isolated subcellular fractions of Alzheimer’s disease brains. Brain Res., 533(1), 125-131.
  • Whanger, PD. (2001). Selenium and the brain: a review. Nutr Neurosci., 4(2), 81-97.
  • Wu, Q., Rayman, MP., Lv, H., Schomburg, L., Cui, B., Gao, C., Chen, P., Zhuang, G., Zhang, Z., Peng, X., Li, H., Zhao, Y., He, X., Zeng, G., Qin, F., Hou, P., & Shi B. (2015). Low Population Selenium Status Is Associated With Increased Prevalence of Thyroid Disease. J Clin Endocrinol Metab., 100(11), 4037-4047.
  • Xia, X., Zhang, X., Liu, M., Duan, M., Zhang, S., Wei, X., Liu, X. (2021). Toward improved human health: efficacy of dietary selenium on immunity at the cellular level. Food Funct., 12(3), 976-989.
  • Yang, T., Lee, SY., Park, KC., Park, SH., Chung, J., & Lee S. (2022). The effects of selenium on bone health: from element to therapeutics. Molecules, 27(2), 392.
  • Yao, Y., Pei, F., & Kang, P. (2011). Selenium, iodine, and the relation with Kashin-Beck disease. Nutrition, 27(11-12), 1095-1100.
  • Zeng, H., Cao, JJ., & Combs, GF. (2013). Selenium in bone health: roles in antioxidant protection and cell proliferation. Nutrients, 5(1), 97-110.
  • Zhao, G., Dong, R., Teng, J., Yang, L., Liu, T., Wu, X., He, Y., Wang, Z., Pu, H., & wang, Y. (2020). N-Acetyl- l -cysteine enhances the effect of selenium nanoparticles on cancer cytotoxicity by increasing the production of selenium-induced reactive oxygen species. ACS Omega., 5(20), 11710-11720.

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Life as Basic
Science: An Overview and Prospects for the Future Volume: 2

How to Cite
Dr. Prosenjt Ghosh (2024). A Short Review on Beneficial Effects of Selenium on Human Health. © International Academic Publishing House (IAPH), Dr. Somnath Das, Dr. Latoya Appleton, Dr. Jayanta Kumar Das, Madhumita Das(eds.), Life as Basic Science: An Overview and Prospects for the Future Volume: 2, pp.148-158. ISBN: 978-81-969828-6-7DOI: https://doi.org/10.52756/lbsopf.2024.e02.013

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