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Anticancer And Antidiabetic Potential of Phytochemicals Derived from Catharanthus roseus: A Key Emphasis to Vinca Alkaloids

Aloke Saha
Department of Zoology, University of Kalyani, Kalyani 741235, West Bengal, India.
OrchideID Icon https://orcid.org/0000-0001-9985-3481

Susmita Moitra
Department of Zoology, University of Kalyani, Kalyani 741235, West Bengal, India.
OrchideID Icon https://orcid.org/0000-0003-4138-9262

Tanmay Sanyal
Department of Zoology, Krishnagar Govt. College, Krishnagar 741101, West Bengal, India.
OrchideID Icon https://orcid.org/0000-0002-0046-1080

DOI: https://doi.org/10.52756/bhietm.2022.e01.001

Keywords: Diabetes, Cancer, Phytomedicine, Catharanthus roseus, Ethnobotany.

Abstract:

Catharanthus roseus is a widely used medicinal herb in several regions of the world. It has already gained popularity because of the discovery of numerous phytoconstituents with diverse biological properties like antioxidant, antimicrobial, antifungal, hypoglycaemic, and anticancer properties. Cancer treatments involve surgical intervention, chemotherapy, radiotherapy, as well as pharmacotherapy, among other things, that not just have a significant financial impact on the patients. Still, it also leads to chronic drug resistance in patients over time. Plant-based drugs have emerged as effective precautionary chemotherapies in both developing and advanced nations. Surprisingly, the plant-derived anticancer agent vinblastine as well as vincristine were the first phytoconstituents to be utilised for drug development. In vitro suppression of human breast cancer cell lines was successfully demonstrated by new isolated biologically active compounds from this plant, such as catharoseumine, 17-deacetoxy-cyclovinblastine etc. Furthermore, vindoline, vindolicine, vindolinine and vindolidine extracted from Catharanthus roseus plant displayed anti-diabetic or antihyperglycaemic activity in vitro. Such findings strongly suggest how this plant has become a viable source of biologically active compounds and needs to be analysed further. This article highlights the function and sources of bioactive compounds derived from Catharanthus roseus, as well as the traditional uses and characteristics of phytoconstituents of this plant. Furthermore, the potential advantages of bioactive components found in Catharanthus roseus were reviewed in order to promote their potential as therapeutics.

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How to Cite
Aloke Saha, Susmita Moitra and Tanmay Sanyal (2022). Anticancer and Antidiabetic Potential of Phytochemicals Derived from Catharanthus roseus: A Key Emphasis to Vinca Alkaloids. © International Academic Publishing House (IAPH), B. Sarkar (eds.), The Basic Handbook of Indian Ethnobotany and Traditional Medicine,Vol. 1, pp. 01-19.
DOI: https://doi.org/10.52756/bhietm.2022.e01.001

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