References:

• Ahmad, H., Arya, A., Agrawal, S., Mall, P., Samuel, S. S., Sharma, K., … & Dwivedi, A. K. (2016a). Rutin phospholipid complexes confer neuro-protection in ischemic-stroke rats. RSC advances, 6(99), 96445-96454. https://doi.org/10.1039/C6RA17874J
• Ahmad, H., Arya, A., Agrawal, S., Samuel, S. S., Singh, S. K., Valicherla, G. R., Sangwan, N., Mitra, K., Gayen, J. R., Paliwal, S., Shukla, R., & Dwivedi, A. K. (2016b). Phospholipid complexation of NMITLI118RT+: way to a prudent therapeutic approach for beneficial outcomes in ischemic stroke in rats. Drug delivery, 23(9), 3606–3618. https://doi.org/10.1080/10717544.2016.1212950
• Alam, M. A., Al-Jenoobi, F. I., & Al-Mohizea, A. M. (2013). Commercially bioavailable proprietary technologies and their marketed products. Drug discovery today, 18(19-20), 936–949. https://doi.org/10.1016/j.drudis.2013.05.007
• Albrigo, R., Andreoni, C., Anello, G., Barboni, M. G., Barzaghi, E., Bianchi, D., … & Giacomelli, L. (2019). Nédemax® mese (Leucoselect®, Lymphaselect®, bromelain) in the treatment of chronic venous disease: a multicenter, observational study. Acta Phlebol, 20(1), 8-14. https://doi.org/10.23736/S1593-232X.19.00437-5
• Albrigo, R., Andreoni, C., Anello, G., Barboni, M. G., Barzaghi, E., Bianchi, D., … & Giacomelli, L. (2019). Nédemax® mese (Leucoselect®, Lymphaselect®, bromelain) in the treatment of chronic venous disease: a multicenter, observational study. Acta Phlebol, 20(1), 8-14.
• Alhakamy, N. A., A Fahmy, U., Badr-Eldin, S. M., Ahmed, O., Asfour, H. Z., Aldawsari, H. M., Algandaby, M. M., Eid, B. G., Abdel-Naim, A. B., Awan, Z. A., K Alruwaili, N., & Mohamed, A. I. (2020). Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells. Pharmaceutics, 12(4), 346. https://doi.org/10.3390/pharmaceutics12040346
• Ali, S. O., Darwish, H. A. E. M., & Ismail, N. A. E. F. (2014). Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. Chemico-Biological Interactions, 216, 26-33. https://doi.org/10.1016/j.cbi.2014.03.009
• Al-Kahtani, M., Abdel-Daim, M. M., Sayed, A. A., El-Kott, A., & Morsy, K. (2020). Curcumin phytosome modulates aluminum-induced hepatotoxicity via regulation of antioxidant, Bcl-2, and caspase-3 in rats. Environmental science and pollution research international, 27(17), 21977–21985. https://doi.org/10.1007/s11356-020-08636-0
• Allais, G., D’Andrea, G., Maggio, M., & Benedetto, C. (2013). The efficacy of ginkgolide B in the acute treatment of migraine aura: an open preliminary trial. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 34 Suppl 1, S161–S163. https://doi.org/10.1007/s10072-013-1413-x
• Amit, P. Y. S. T., Tanwar, Y. S., Rakesh, S., & Poojan, P. (2013). Phytosome: Phytolipid drug delivery system for improving bioavailability of herbal drug. J Pharm Sci Biosci Res, 3(2), 51-57. http://jpsbr.com/index_htm_files/2_JPSBR13RV0203.pdf
• Anjana, R., Kumar, S., Sharma, H., & Khar, R. (2017). Phytosome drug delivery of natural products: A promising technique for enhancing bioavailability. International Journal of Drug Delivery Technology, 7(03), 157-165. https://doi.org/10.25258/ijddt.v7i03.9559
• Bahadur, S., Sachan, N., Harwansh, R. K., & Deshmukh, R. (2020). Nanoparticlized System: Promising Approach for the Management of Alzheimer’s Disease through Intranasal Delivery. Current pharmaceutical design, 26(12), 1331–1344. https://doi.org/10.2174/1381612826666200311131658
• Balzano, L., & Ciccone, B. (2018, September). Preliminary efficacy study in prophylaxes of episodic tension cephala and hemicrania without aura using a combination of magnesium, L-triptofano, Boswellia serrata Casperome (r), niacina, riboflavina and vitamin d compared with amitriptiline. In JOURNAL OF HEADACHE AND PAIN (Vol. 19). CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND: SPRINGEROPEN.
• Barani, M., Sangiovanni, E., Angarano, M., Rajizadeh, M. A., Mehrabani, M., Piazza, S., … & Nematollahi, M. H. (2021). Phytosomes as innovative delivery systems for phytochemicals: A comprehensive review of literature. International Journal of Nanomedicine, 16, 6983.  https://doi.org/10.2147/IJN.S318416
• Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., Togni, S., & Appendino, G. (2010). Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Alternative medicine review : a journal of clinical therapeutic, 15(4), 337–344.
• Belcaro, G., Dugall, M., Luzzi, R., Ledda, A., Pellegrini, L., Cesarone, M. R., Hosoi, M., & Errichi, M. (2014). Meriva®+Glucosamine versus Condroitin+Glucosamine in patients with knee osteoarthritis: an observational study. European review for medical and pharmacological sciences, 18(24), 3959–3963. http://www.europeanreview.org/wp/wp-content/uploads/3959-3963.pdf
• Belcaro, G., Gizzi, G., Pellegrini, L., Corsi, M., Dugall, M., Cacchio, M., Feragalli, B., Togni, S., Riva, A., Eggenhoffner, R., & Giacomelli, L. (2017). Supplementation with a lecithin-based delivery form of Boswellia serrata extract (Casperome®) controls symptoms of mild irritable bowel syndrome. European review for medical and pharmacological sciences, 21(9), 2249–2254.
• Bhattacharya, S. (2009). Phytosomes: the new technology for enhancement of bioavailability of botanicals and nutraceuticals. International Journal of Health Research, 2(3), 225-232. https://doi.org/10.4314/ijhr.v2i3.47905
• Bombardelli, E., Curri, S. B., Della Loggia, R., Del Negro, P., Gariboldi, P., & Tubaro, A. (1989). Anti-inflammatory activity of 18-ß-glycyrrhetinic acid in phytosome form 29-37.
• Carini, M., Aldini, G., Bombardelli, E., Morazzoni, P., & Morelli, R. (1994). Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittel-Forschung, 44(5), 592-601.
• Cesarone, M. R., Belcaro, G., Hu, S., Dugall, M., Hosoi, M., Ledda, A., Feragalli, B., Maione, C., & Cotellese, R. (2019). Supplementary prevention and management of asthma with quercetin phytosome: a pilot registry. Minerva medica, 110(6), 524–529. https://doi.org/10.23736/S0026-4806.19.06319-5
• Cesarone, M. R., Belcaro, G., Hu, S., Dugall, M., Hosoi, M., Ledda, A., Feragalli, B., Maione, C., & Cotellese, R. (2019). Supplementary prevention and management of asthma with quercetin phytosome: a pilot registry. Minerva medica, 110(6), 524–529. https://doi.org/10.23736/S0026-4806.19.06319-5
• Chandra, D., Jahangir, A., Cornelis, F., Rombauts, K., Meheus, L., Jorcyk, C. L., & Gravekamp, C. (2015). Cryoablation and Meriva have strong therapeutic effect on triple-negative breast cancer. Oncoimmunology, 5(1), e1049802. https://doi.org/10.1080/2162402X.2015.1049802
• Chen X-M, Wu XK, Kong DG, Chen S. Preparation and preliminary study of quality evaluation of ginsenosides phospholipid compound. Qilu Pharma Spain. 2011;9:102–114. 
• Cheng, C., Wu, Z., McClements, D. J., Zou, L., Peng, S., Zhou, W., & Liu, W. (2019). Improvement on stability, loading capacity and sustained release of rhamnolipids modified curcumin liposomes. Colloids and surfaces B: biointerfaces, 183, 110460. https://doi.org/10.1016/j.colsurfb.2019.110460
• Cheng, C., Wu, Z., McClements, D. J., Zou, L., Peng, S., Zhou, W., & Liu, W. (2019). Improvement on stability, loading capacity and sustained release of rhamnolipids modified curcumin liposomes. Colloids and surfaces. B, Biointerfaces, 183, 110460. https://doi.org/10.1016/j.colsurfb.2019.110460
• Chibowski, E., & Szcześ, A. (2016). Zeta potential and surface charge of DPPC and DOPC liposomes in the presence of PLC enzyme. Adsorption, 22(4), 755-765. https://doi.org/10.1007/s10450-016-9767-z
• D’Andrea, G., Bussone, G., Allais, G., Aguggia, M., D’Onofrio, F., Maggio, M., Moschiano, F., Saracco, M. G., Terzi, M. G., Petretta, V., & Benedetto, C. (2009). Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 30 Suppl 1, S121–S124. https://doi.org/10.1007/s10072-009-0074-2
• Dayan, N., & Touitou, E. (2000). Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs. liposomes. Biomaterials, 21(18), 1879-1885.
• Dell’Agli, M., Sangiovanni, E., Risè, P., Rossetti, A. C., Morazzoni, P., Riva, A., … & Molteni, R. (2016). Bioavailability of curcumin in the rat frontal lobe and hippocampus after repeated administration of MERIVA®. Planta Medica, 82(S 01), P895.
• Di Pierro, F., & Settembre, R. (2013). Safety and efficacy of an add-on therapy with curcumin phytosome and piperine and/or lipoic acid in subjects with a diagnosis of peripheral neuropathy treated with dexibuprofen. Journal of pain research, 6, 497–503. https://doi.org/10.2147/JPR.S48432
• Di Pierro, F., Derosa, G., Maffioli, P., Bertuccioli, A., Togni, S., Riva, A., Allegrini, P., Khan, A., Khan, S., Khan, B. A., Altaf, N., Zahid, M., Ujjan, I. D., Nigar, R., Khushk, M. I., Phulpoto, M., Lail, A., Devrajani, B. R., & Ahmed, S. (2021b). Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study. International journal of general medicine, 14, 2359–2366. https://doi.org/10.2147/IJGM.S318720
• Di Pierro, F., Iqtadar, S., Khan, A., Ullah Mumtaz, S., Masud Chaudhry, M., Bertuccioli, A., Derosa, G., Maffioli, P., Togni, S., Riva, A., Allegrini, P., & Khan, S. (2021c). Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial. International journal of general medicine, 14, 2807–2816. https://doi.org/10.2147/IJGM.S318949
• DI Pierro, F., Khan, A., Bertuccioli, A., Maffioli, P., Derosa, G., Khan, S., Khan, B. A., Nigar, R., Ujjan, I., & Devrajani, B. R. (2021a). Quercetin Phytosome® as a potential candidate for managing COVID-19. Minerva gastroenterology, 67(2), 190–195. https://doi.org/10.23736/S2724-5985.20.02771-3
• Di Pierro, F., Menghi, A. B., Barreca, A., Lucarelli, M., & Calandrelli, A. (2009). Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Alternative medicine review: a journal of clinical therapeutic, 14(2), 154–160.
• Di Pierro, F., Rapacioli, G., Di Maio, E. A., Appendino, G., Franceschi, F., & Togni, S. (2013). Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophen. Journal of pain research, 6, 201–205. https://doi.org/10.2147/JPR.S42184
• Di Pierro, F., Simonetti, G., Petruzzi, A., Bertuccioli, A., Botta, L., Bruzzone, M. G., Cuccarini, V., Fariselli, L., & Lamperti, E. (2019). A novel lecithin-based delivery form of Boswellic acids as complementary treatment of radiochemotherapy-induced cerebral edema in patients with glioblastoma multiforme: a longitudinal pilot experience. Journal of neurosurgical sciences, 63(3), 286–291. https://doi.org/10.23736/S0390-5616.19.04662-9
• Di Pierro, F., Togni, S., Franceschi, F., Eghenhofner, R., & Giacomelli, L. (2016). Effects of standardized Ginkgo biloba extract complexed with phosphatidylserine (Virtiva®) on physiological response to prolonged, intense physical activity. Minerva Ortop Traumatol, 67(3), 119-123.
• Di Pierro, F., Zacconi, P., Bertuccioli, A., Togni, S., Eggenhoffner, R., Giacomelli, L., & Scaltrini, S. (2017). A naturally-inspired, curcumin-based lecithin formulation (Meriva® formulated as the finished product Algocur®) alleviates the osteo-muscular pain conditions in rugby players. European review for medical and pharmacological sciences, 21(21), 4935–4940. PMID: 29164565
• Djekic, L., Čalija, B., Micov, A., Tomić, M., & Stepanović-Petrović, R. (2019). Topical hydrogels with escin β-sitosterol phytosome and escin: Formulation development and in vivo assessment of antihyperalgesic activity. Drug development research, 80(7), 921–932. https://doi.org/10.1002/ddr.21572
• Drobnic, F., Riera, J., Appendino, G., Togni, S., Franceschi, F., Valle, X., Pons, A., & Tur, J. (2014). Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial. Journal of the International Society of Sports Nutrition, 11, 31. https://doi.org/10.1186/1550-2783-11-31
• Drobnic, F., Riera, J., Appendino, G., Togni, S., Franceschi, F., Valle, X., Pons, A., & Tur, J. (2014). Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial. Journal of the International Society of Sports Nutrition, 11, 31. https://doi.org/10.1186/1550-2783-11-31
• El-Far, S. W., Helmy, M. W., Khattab, S. N., Bekhit, A. A., Hussein, A. A., & Elzoghby, A. O. (2018a). Phytosomal bilayer-enveloped casein micelles for codelivery of monascus yellow pigments and resveratrol to breast cancer. Nanomedicine (London, England), 13(5), 481–499. https://doi.org/10.2217/nnm-2017-0301
• El-Far, S. W., Helmy, M. W., Khattab, S. N., Bekhit, A. A., Hussein, A. A., & Elzoghby, A. O. (2018b). Folate conjugated vs PEGylated phytosomal casein nanocarriers for codelivery of fungal- and herbal-derived anticancer drugs. Nanomedicine (London, England), 13(12), 1463–1480. https://doi.org/10.2217/nnm-2018-0006
• El-Gazayerly, O. N., Makhlouf, A. I., Soelm, A. M., & Mohmoud, M. A. (2014). Antioxidant and hepatoprotective effects of silymarin phytosomes compared to milk thistle extract in CCl4 induced hepatotoxicity in rats. Journal of microencapsulation, 31(1), 23–30. https://doi.org/10.3109/02652048.2013.805836
• El-Menshawe, S. F., Ali, A. A., Rabeh, M. A., & Khalil, N. M. (2018). Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product. International journal of nanomedicine, 13, 307–318. https://doi.org/10.2147/IJN.S153429
• Feragalli, B., Ippolito, E., Dugall, M., Cacchio, M., Belcaro, G., Cesarone, M. R., Abdel-Tawab, M., Riva, A., Togni, S., Eggenhoffner, R., & Giacomelli, L. (2017). Effectiveness of a novel boswellic acids delivery form (Casperome®) in the management of grade II ankle sprains due to sport trauma – a registry study. European review for medical and pharmacological sciences, 21(20), 4726–4732. PMID: 29131239
• Ferrara, T., De Vincentiis, G., & Di Pierro, F. (2015). Functional study on Boswellia phytosome as complementary intervention in asthmatic patients. European review for medical and pharmacological sciences, 19(19), 3757–3762. PMID: 26502867
• Franceschi, F., Feregalli, B., Togni, S., Cornelli, U., Giacomelli, L., Eggenhoffner, R., & Belcaro, G. (2016). A novel phospholipid delivery system of curcumin (Meriva®) preserves muscular mass in healthy aging subjects. European review for medical and pharmacological sciences, 20(4), 762–766. PMID: 26957282
• Franceschi, F., Togni, S., Belcaro, G., Dugall, M., Luzzi, R., Ledda, A., Pellegrini, L., Eggenhoffner, R., & Giacomelli, L. (2016). A novel lecithin-based delivery form of Boswellic acids (Casperome®) for the management of osteo-muscular pain: a registry study in young rugby players. European review for medical and pharmacological sciences, 20(19), 4156–4161. PMID: 27775780
• Franco, P. G., & Bombardelli, E. (1998). Complex compounds of bioflavonoids with phospholipids, their preparation and uses and pharmaceutical and cosmetic compositions containing them. US Patent No-EPO, 275005.
• Freag, M. S., Elnaggar, Y. S., & Abdallah, O. Y. (2013). Lyophilized phytosomal nanocarriers as platforms for enhanced diosmin delivery: optimization and ex vivo permeation. International journal of nanomedicine, 8, 2385. https://doi.org/10.2147%2FIJN.S45231
• Freag, M. S., Saleh, W. M., & Abdallah, O. Y. (2018). Self-assembled phospholipid-based phytosomal nanocarriers as promising platforms for improving oral bioavailability of the anticancer celastrol. International journal of pharmaceutics, 535(1-2), 18-26. https://doi.org/10.1016/j.ijpharm.2017.10.053
• Ghanbarzadeh, B., Babazadeh, A., & Hamishehkar, H. (2016). Nano-phytosome as a potential food-grade delivery system. Food bioscience, 15, 126-135. https://doi.org/10.1016/j.fbio.2016.07.006
• Gilardini, L., Pasqualinotto, L., Di Pierro, F., Risso, P., & Invitti, C. (2016). Effects of Greenselect Phytosome® on weight maintenance after weight loss in obese women: a randomized placebo-controlled study. BMC complementary and alternative medicine, 16, 233. https://doi.org/10.1186/s12906-016-1214-x
• Gurunathan, S., Kang, M. H., Qasim, M., & Kim, J. H. (2018). Nanoparticle-mediated combination therapy: Two-in-one approach for cancer. International journal of molecular sciences, 19(10), 3264. https://doi.org/10.3390/ijms19103264
• Habbu, P., Madagundi, S., Shastry, R., Vanakudri, R., & Kulkarni, V. (2015). Preparation and evaluation of antidiabetic activity of allium cepa-phospholipid complex (phytosome) in streptozotocin induced diabetic rats. RGUHS J Pharm Sci, 5(4), 132-141.
• Haddad, Y., Vallerand, D., Brault, A., & Haddad, P. S. (2011). Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis. Evidence-based complementary and alternative medicine : eCAM, 2011, nep164. https://doi.org/10.1093/ecam/nep164
• Hashemzehi, M., Behnam-Rassouli, R., Hassanian, S. M., Moradi-Binabaj, M., Moradi-Marjaneh, R., Rahmani, F., Fiuji, H., Jamili, M., Mirahmadi, M., Boromand, N., Piran, M., Jafari, M., Sahebkar, A., Avan, A., & Khazaei, M. (2018). Phytosomal-curcumin antagonizes cell growth and migration, induced by thrombin through AMP-Kinase in breast cancer. Journal of cellular biochemistry, 119(7), 5996–6007. https://doi.org/10.1002/jcb.26796
• He, N., Zhang, L., Zhu, F., Rui, K., Yuan, M. Q., & Qin, H. (2010). Formulation of self-nanoemulsifying drug delivery systems for insulin-soybean lecithin complex. West China J Pharm Sci, 25(4), 396-399.
• Ho, P. J., Sung, J. J., Cheon, K. K., & Tae, H. J. (2018). Anti-inflammatory effect of Centella asiatica phytosome in a mouse model of phthalic anhydride-induced atopic dermatitis. Phytomedicine, 43, 110-119. https://doi.org/10.1016/j.phymed.2018.04.013
• Howells, L. M., Sale, S., Sriramareddy, S. N., Irving, G. R., Jones, D. J., Ottley, C. J., Pearson, D. G., Mann, C. D., Manson, M. M., Berry, D. P., Gescher, A., Steward, W. P., & Brown, K. (2011). Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. International journal of cancer, 129(2), 476–486. https://doi.org/10.1002/ijc.25670
• Huang, Z., Brennan, C. S., Zhao, H., Liu, J., Guan, W., Mohan, M. S., Stipkovits, L., Zheng, H., & Kulasiri, D. (2020). Fabrication and assessment of milk phospholipid-complexed antioxidant phytosomes with vitamin C and E: A comparison with liposomes. Food chemistry, 324, 126837. https://doi.org/10.1016/j.foodchem.2020.126837
• Hüsch, J., Bohnet, J., Fricker, G., Skarke, C., Artaria, C., Appendino, G., Schubert-Zsilavecz, M., & Abdel-Tawab, M. (2013). Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract. Fitoterapia, 84, 89–98. https://doi.org/10.1016/j.fitote.2012.10.002
• Ibrahim, A., El-Meligy, A., Fetaih, H., Dessouki, A., Stoica, G., & Barhoumi, R. (2010). Effect of curcumin and Meriva on the lung metastasis of murine mammary gland adenocarcinoma. In vivo (Athens, Greece), 24(4), 401–408. https://iv.iiarjournals.org/content/invivo/24/4/401.full.pdf
• JA, S. S. (2011). Phytosome: an emerging trend in herbal drug treatment. Journal of Medical Genetics and Genomics, 3(6), 109-114.
• Jain, N. K., & Jain, N. K. (2005). Liposomes as drug carriers, controlled and novel drug delivery. CBS publisher, 308, 321-326. ISBN: 978-953-51-1628-8
• Jain, S., Dhanotiya, C., & Malviya, N. (2012). Physicochemical characterization and determination of free radical scavenging activity of rutin-phospholipid complex. International Journal of Pharmaceutical Sciences and Research, 3(3), 909. https://doi.org/10.3390/molecules14093486
• Kalita, B., Das, M. K., & Sharma, A. K. (2013). Novel phytosome formulations in making herbal extracts more effective. J Pharm Technol, 6(11), 1295-1301.
• Karole, S., & Gupta, G. K. G. S. (2019). Preparation and evaluation of phytosomes containing ethanolic extract of leaves of Bombax ceiba for hepatoprotective activity. Evaluation, 6(2), 1-5. https://www.thepharmajournal.com/archives/2019/vol8issue2/PartA/8-1-61-396.pdf
• Khan, J., Alexander, A., Saraf, S., & Saraf, S. (2013). Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. Journal of controlled release, 168(1), 50-60. https://doi.org/10.1016/j.jconrel.2013.02.025
• Khan, J., Alexander, A., Saraf, S., & Saraf, S. (2013). Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. Journal of controlled release, 168(1), 50-60. https://doi.org/10.1016/j.jconrel.2013.02.025
• Kidd, P., & Head, K. (2005). A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Alternative medicine review : a journal of clinical therapeutic, 10(3), 193–203.
• Kiefer, D., & Pantuso, T. (2003). Panax ginseng. American family physician, 68(8), 1539–1542.
• Kondratyuk, T. P., & Pezzuto, J. M. (2004). Natural product polyphenols of relevance to human health. Pharmaceutical biology, 42(sup1), 46-63.
• La Grange, L., Wang, M., Watkins, R., Ortiz, D., Sanchez, M. E., Konst, J., Lee, C., & Reyes, E. (1999). Protective effects of the flavonoid mixture, silymarin, on fetal rat brain and liver. Journal of ethnopharmacology, 65(1), 53–61. https://doi.org/10.1016/s0378-8741(98)00144-5
• Langasco, R., Fancello, S., Rassu, G., Cossu, M., Cavalli, R., Galleri, G., Giunchedi, P., Migheli, R., & Gavini, E. (2019). Increasing protective activity of genistein by loading into transfersomes: A new potential adjuvant in the oxidative stress-related neurodegenerative diseases?. Phytomedicine : international journal of phytotherapy and phytopharmacology, 52, 23–31. https://doi.org/10.1016/j.phymed.2018.09.207
• Lazzeroni, M., Guerrieri-Gonzaga, A., Gandini, S., Johansson, H., Serrano, D., Cazzaniga, M., Aristarco, V., Puccio, A., Mora, S., Caldarella, P., Pagani, G., Pruneri, G., Riva, A., Petrangolini, G., Morazzoni, P., DeCensi, A., & Bonanni, B. (2016). A Presurgical Study of Oral Silybin-Phosphatidylcholine in Patients with Early Breast Cancer. Cancer prevention research (Philadelphia, Pa.), 9(1), 89–95. https://doi.org/10.1158/1940-6207.CAPR-15-0123
• Ledda, A., Belcaro, G., Dugall, M., Luzzi, R., Scoccianti, M., Togni, S., Appendino, G., & Ciammaichella, G. (2012). Meriva®, a lecithinized curcumin delivery system, in the control of benign prostatic hyperplasia: a pilot, product evaluation registry study. Panminerva medica, 54(1 Suppl 4), 17–22. PMID: 23241931
• Ledda, A., Belcaro, G., Feragalli, B., Hosoi, M., Cacchio, M., Luzzi, R., … & Cotellese, R. (2018). Temporary kidney dysfunction: supplementation with Meriva® in initial, transient kidney micro-macro albuminuria. Panminerva Medica, 61(4), 444-448. https://doi.org/10.23736/S0031-0808.18.03575-9
• Li, F., Yang, X., Yang, Y., Li, P., Yang, Z., & Zhang, C. (2015). Phospholipid complex as an approach for bioavailability enhancement of echinacoside. Drug development and industrial pharmacy, 41(11), 1777–1784. https://doi.org/10.3109/03639045.2015.1004183
• Li, J., Wang, X., Zhang, T., Wang, C., Huang, Z., Luo, X., & Deng, Y. (2015). A review on phospholipids and their main applications in drug delivery systems. Asian journal of pharmaceutical sciences, 10(2), 81-98. https://doi.org/10.1016/j.ajps.2014.09.004
• Lim, A. W., Ng, P. Y., Chieng, N., & Ng, S. F. (2019). Moringa oleifera leaf extract–loaded phytophospholipid complex for potential application as wound dressing. Journal of Drug Delivery Science and Technology, 54, 101329. https://doi.org/10.1016/j.jddst.2019.101329
• Liu, S. (2012). Preparation, characterization and in vitro anti-tumor activities of evodiamine phospholipids complex. Chinese Pharmaceutical Journal, 517-523.
• Liu, Y., Huang, P., Hou, X., Yan, F., Jiang, Z., Shi, J., … & Feng, N. (2019). Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer. International Journal of Nanomedicine, 14, 3311. https://doi.org/10.2147/ijn.s200847
• Liu, Z., Wang, J., Gao, W., Man, S., Guo, H., Zhang, J., & Liu, C. (2013). Formulation and in vitro absorption analysis of Rhizoma paridis steroidal saponins. International journal of pharmaceutics, 441(1-2), 680–686. https://doi.org/10.1016/j.ijpharm.2012.10.028
• Loeser, K., Seemann, S., König, S., Lenhardt, I., Abdel-Tawab, M., Koeberle, A., Werz, O., & Lupp, A. (2018). Protective Effect of Casperome^®, an Orally Bioavailable Frankincense Extract, on Lipopolysaccharide- Induced Systemic Inflammation in Mice. Frontiers in pharmacology, 9, 387. https://doi.org/10.3389/fphar.2018.00387
• Loguercio, C., Andreone, P., Brisc, C., Brisc, M. C., Bugianesi, E., Chiaramonte, M., Cursaro, C., Danila, M., de Sio, I., Floreani, A., Freni, M. A., Grieco, A., Groppo, M., Lazzari, R., Lobello, S., Lorefice, E., Margotti, M., Miele, L., Milani, S., Okolicsanyi, L., … Federico, A. (2012). Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free radical biology & medicine, 52(9), 1658–1665. https://doi.org/10.1016/j.freeradbiomed.2012.02.008
• Lu, M., Qiu, Q., Luo, X., Liu, X., Sun, J., Wang, C., Lin, X., Deng, Y., & Song, Y. (2019). Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents. Asian journal of pharmaceutical sciences, 14(3), 265–274. https://doi.org/10.1016/j.ajps.2018.05.011
• Magrone, T., Pugliese, V., Fontana, S., & Jirillo, E. (2014). Human use of Leucoselect® Phytosome® with special reference to inflammatory-allergic pathologies in frail elderly patients. Current pharmaceutical design, 20(6), 1011–1019. https://doi.org/10.2174/138161282006140220144411
• Mahmoodi, N., Motamed, N., Paylakhi, S. H., & O Mahmoodi, N. (2015). Comparing the Effect of Silybin and Silybin Advanced™ on Viability and HER2 Expression on the Human Breast Cancer SKBR3 Cell Line by no Serum Starvation. Iranian journal of pharmaceutical research: IJPR, 14(2), 521–530. https://pubmed.ncbi.nlm.nih.gov/25901160
• Maida, G. (2016). Clinical usefulness of oral supplementation with curcumin phytosome in patients with radiculopathy due to spondyloarthritis or discopathy. Minerva Ortop Traumatol, 67(2), 75-78.
• Maiti, P., & Dunbar, G. L. (2018). Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases. International journal of molecular sciences, 19(6), 1637. https://doi.org/10.3390/ijms19061637
• Mancini, S., Nardo, L., Gregori, M., Ribeiro, I., Mantegazza, F., Delerue-Matos, C., Masserini, M., & Grosso, C. (2018). Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds. Phytomedicine: international journal of phytotherapy and phytopharmacology, 42, 233–244. https://doi.org/10.1016/j.phymed.2018.03.053
• Mao, J. T., Xue, B., Fan, S., Neis, P., Qualls, C., Massie, L., & Fiehn, O. (2021). Leucoselect Phytosome Modulates Serum Eicosapentaenoic Acid, Docosahexaenoic Acid, and Prostaglandin E3 in a Phase I Lung Cancer Chemoprevention Study. Cancer prevention research (Philadelphia, Pa.), 14(6), 619–626. https://doi.org/10.1158/1940-6207.CAPR-20-0585
• Marjaneh, R. M., Rahmani, F., Hassanian, S. M., Rezaei, N., Hashemzehi, M., Bahrami, A., Ariakia, F., Fiuji, H., Sahebkar, A., Avan, A., & Khazaei, M. (2018). Phytosomal curcumin inhibits tumor growth in colitis-associated colorectal cancer. Journal of cellular physiology, 233(10), 6785–6798. https://doi.org/10.1002/jcp.26538
• Maryana, W., Rachmawati, H., & Mudhakir, D. (2016). Formation of phytosome containing silymarin using thin layer-hydration technique aimed for oral delivery. Materials today: proceedings, 3(3), 855-866. https://doi.org/10.1016/j.matpr.2016.02.019
• Mazumder, A., Dwivedi, A., Du Preez, J. L., & Du Plessis, J. (2016). In vitro wound healing and cytotoxic effects of sinigrin–phytosome complex. International journal of pharmaceutics, 498(1-2), 283-293. https://doi.org/10.1016/j.ijpharm.2015.12.027
• Minaei, A., Sabzichi, M., Ramezani, F., Hamishehkar, H., & Samadi, N. (2016). Co-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cells. Molecular biology reports, 43(2), 99–105. https://doi.org/10.1007/s11033-016-3942-x
• Miserocchi, E., Giuffrè, C., Cicinelli, M. V., Marchese, A., Gattinara, M., Modorati, G., & Bandello, F. (2020). Oral phospholipidic curcumin in juvenile idiopathic arthritis-associated uveitis. European journal of ophthalmology, 30(6), 1390–1396. https://doi.org/10.1177/1120672119892804
• Mollace, V., Scicchitano, M., Paone, S., Casale, F., Calandruccio, C., Gliozzi, M., Musolino, V., Carresi, C., Maiuolo, J., Nucera, S., Riva, A., Allegrini, P., Ronchi, M., Petrangolini, G., & Bombardelli, E. (2019). Hypoglycemic and Hypolipemic Effects of a New Lecithin Formulation of Bergamot Polyphenolic Fraction: A Double Blind, Randomized, Placebo- Controlled Study. Endocrine, metabolic & immune disorders drug targets, 19(2), 136–143. https://doi.org/10.2174/1871530319666181203151513
• Moradi-Marjaneh, R., Hassanian, S. M., Rahmani, F., Aghaee-Bakhtiari, S. H., Avan, A., & Khazaei, M. (2018). Phytosomal Curcumin Elicits Anti-tumor Properties Through Suppression of Angiogenesis, Cell Proliferation and Induction of Oxidative Stress in Colorectal Cancer. Current pharmaceutical design, 24(39), 4626–4638. https://doi.org/10.2174/1381612825666190110145151
• Mukherjee, S., Baidoo, J., Fried, A., Atwi, D., Dolai, S., Boockvar, J., Symons, M., Ruggieri, R., Raja, K., & Banerjee, P. (2016). Curcumin changes the polarity of tumor-associated microglia and eliminates glioblastoma. International journal of cancer, 139(12), 2838–2849. https://doi.org/10.1002/ijc.30398
• Mukherjee, S., Fried, A., Hussaini, R., White, R., Baidoo, J., Yalamanchi, S., & Banerjee, P. (2018). Phytosomal curcumin causes natural killer cell-dependent repolarization of glioblastoma (GBM) tumor-associated microglia/macrophages and elimination of GBM and GBM stem cells. Journal of experimental & clinical cancer research : CR, 37(1), 168. https://doi.org/10.1186/s13046-018-0792-5
• Nagar, G. (2019). Phytosomes: a novel drug delivery for herbal extracts. Int J Pharm Sci Res, 949-59. http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).949-59
• Naik, S. R., & Panda, V. S. (2007). Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents. Liver international : official journal of the International Association for the Study of the Liver, 27(3), 393–399. https://doi.org/10.1111/j.1478-3231.2007.01463.x
• Naik, S. R., & Panda, V. S. (2008). Hepatoprotective effect of Ginkgoselect Phytosome in rifampicin induced liver injury in rats: evidence of antioxidant activity. Fitoterapia, 79(6), 439–445. https://doi.org/10.1016/j.fitote.2008.02.013
• Naik, S. R., Pilgaonkar, V. W., & Panda, V. S. (2006). Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain. Phytotherapy research : PTR, 20(11), 1013–1016. https://doi.org/10.1002/ptr.1976
• Naik, S. R., Pilgaonkar, V. W., & Panda, V. S. (2006a). Neuropharmacological evaluation of Ginkgo biloba phytosomes in rodents. Phytotherapy research : PTR, 20(10), 901–905. https://doi.org/10.1002/ptr.1973
• Naik, S. R., Pilgaonkar, V. W., & Panda, V. S. (2006b). Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain. Phytotherapy research : PTR, 20(11), 1013–1016. https://doi.org/10.1002/ptr.1976
• Nuttall, S. L., Kendall, M. J., Bombardelli, E., & Morazzoni, P. (1998). An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect®. Journal of clinical pharmacy and therapeutics, 23(5), 385-389.https://doi.org/10.1046/j.1365-2710.1998.00180.x
• Ojha, S. (2018). In vitro and In vivo neuroprotective study of solid lipid nanoparticles loaded with dimethyl fumarate. Asian Journal of Pharmaceutics (AJP), 12(01). https://doi.org/10.22377/ajp.v12i01.2044
• Pajardi, G., Bortot, P., Ponti, V., & Novelli, C. (2014). Clinical usefulness of oral supplementation with alpha-lipoic Acid, curcumin phytosome, and B-group vitamins in patients with carpal tunnel syndrome undergoing surgical treatment. Evidence-based complementary and alternative medicine: eCAM, 2014, 891310. https://doi.org/10.1155/2014/891310
• Panda, V. S., & N, S. R. (2009). Evaluation of cardioprotective activity of Ginkgo biloba and Ocimum sanctum in rodents. Alternative medicine review: a journal of clinical therapeutic, 14(2), 161–171. https://altmedrev.com/wp-content/uploads/2019/02/v14-2-161.pdf
• Panda, V. S., & Naik, S. R. (2008). Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 60(4-5), 397–404. https://doi.org/10.1016/j.etp.2008.03.010
• Pastorelli, D., Fabricio, A. S., Giovanis, P., D’Ippolito, S., Fiduccia, P., Soldà, C., … & Ursini, F. (2018). Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial. Pharmacological research, 132, 72-79. https://doi.org/10.1016/j.phrs.2018.03.013
• Patel, J., Patel, R., Khambholja, K., & Patel, N. (2009). An overview of phytosomes as an advanced herbal drug delivery system. Asian J Pharm Sci, 4(6), 363-371.  10.19080/CTBEB.2017.03.555621
• Pathan, R. A., & Bhandari, U. (2011). Preparation & characterization of embelin–phospholipid complex as effective drug delivery tool. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 69(1), 139-147. https://doi.org/10.1007/s10847-010-9824-2
• Pellegrini, L., Milano, E., Franceschi, F., Belcaro, G., Gizzi, G., Feragalli, B., Dugall, M., Luzzi, R., Togni, S., Eggenhoffner, R., & Giacomelli, L. (2016). Managing ulcerative colitis in remission phase: usefulness of Casperome®, an innovative lecithin-based delivery system of Boswellia serrata extract. European review for medical and pharmacological sciences, 20(12), 2695–2700. PMID: 27383325
• Petrangolini, G., Ronchi, M., Frattini, E., De Combarieu, E., Allegrini, P., & Riva, A. (2019). A New Food-grade Coenzyme Q10 Formulation Improves Bioavailability: Single and Repeated Pharmacokinetic Studies in Healthy Volunteers. Current drug delivery, 16(8), 759–767. https://doi.org/10.2174/1567201816666190902123147
• Pucek, A., Niezgoda, N., Kulbacka, J., Wawrzeńczyk, C., & Wilk, K. A. (2017). Phosphatidylcholine with conjugated linoleic acid in fabrication of novel lipid nanocarriers. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 532, 377-388. https://doi.org/10.1016/j.colsurfa.2017.04.061
• Rani, A., Kumar, S., & Khar, R. K. (2019). Casuarina equisetifolia extract loaded phytosomes: Optimization, characterization and in vivo evaluation of antidiabetic and antihyperlipidemic activities in Wistar rats. Drug Delivery Letters, 9(2), 116-133. http://dx.doi.org/10.2174/2210303109666190118162157
• Rathee, S., & Kamboj, A. (2018). Optimization and development of antidiabetic phytosomes by the Box–Behnken design. Journal of liposome research, 28(2), 161-172. https://doi.org/10.1080/08982104.2017.1311913
• Riva, A., Allegrini, P., Franceschi, F., Togni, S., Giacomelli, L., & Eggenhoffner, R. (2017). A novel boswellic acids delivery form (Casperome®) in the management of musculoskeletal disorders: a review. European review for medical and pharmacological sciences, 21(22), 5258–5263. https://doi.org/10.26355/eurrev_201711_13849
• Riva, A., Giacomelli, L., Togni, S., Franceschi, F., Eggenhoffner, R., Zuccarini, M. C., & Belcaro, G. (2019). Oral administration of a lecithin-based delivery form of boswellic acids (Casperome®) for the prevention of symptoms of irritable bowel syndrome: a randomized clinical study. Minerva gastroenterologica e dietologica, 65(1), 30–35. https://doi.org/10.23736/S1121-421X.18.02530-8
• Riva, A., Longo, V., Berlanda, D., Allegrini, P., Masetti, G., Botti, S., & Petrangolini, G. (2020). Healthy Protection of Bergamot is linked to the Modulation of Microbiota. J Appl Microb Res. 2020;3(2):45-51.
• Riva, A., Togni, S., Giacomelli, L., Franceschi, F., Eggenhoffner, R., Feragalli, B., Belcaro, G., Cacchio, M., Shu, H., & Dugall, M. (2017). Effects of a curcumin-based supplementation in asymptomatic subjects with low bone density: a preliminary 24-week supplement study. European review for medical and pharmacological sciences, 21(7), 1684–1689.
• Rondanelli, M., Perna, S., Gasparri, C., Petrangolini, G., Allegrini, P., Cavioni, A., Faliva, M. A., Mansueto, F., Patelli, Z., Peroni, G., Tartara, A., & Riva, A. (2022). Promising Effects of 3-Month Period of Quercetin Phytosome^® Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study. Life (Basel, Switzerland), 12(1), 66. https://doi.org/10.3390/life12010066
• Rondanelli, M., Riva, A., Allegrini, P., Faliva, M. A., Naso, M., Peroni, G., Nichetti, M., Gasparri, C., Spadaccini, D., Iannello, G., Infantino, V., Fazia, T., Bernardinelli, L., & Perna, S. (2020). The Use of a New Food-Grade Lecithin Formulation of Highly Standardized Ginger (Zingiber officinale) and Acmella oleracea Extracts for the Treatment of Pain and Inflammation in a Group of Subjects with Moderate Knee Osteoarthritis. Journal of pain research, 13, 761–770. https://doi.org/10.2147/JPR.S214488
• Sabzichi, M., Hamishehkar, H., Ramezani, F., Sharifi, S., Tabasinezhad, M., Pirouzpanah, M., Ghanbari, P., & Samadi, N. (2014). Luteolin-loaded phytosomes sensitize human breast carcinoma MDA-MB 231 cells to doxorubicin by suppressing Nrf2 mediated signalling. Asian Pacific journal of cancer prevention: APJCP, 15(13), 5311–5316. https://doi.org/10.7314/apjcp.2014.15.13.5311
• Sbrini, G., Brivio, P., Fumagalli, M., Giavarini, F., Caruso, D., Racagni, G., Dell’Agli, M., Sangiovanni, E., & Calabrese, F. (2020a). Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex. Nutrients, 12(2), 355. https://doi.org/10.3390/nu12020355
• Sbrini, G., Brivio, P., Fumagalli, M., Giavarini, F., Caruso, D., Racagni, G., Dell’Agli, M., Sangiovanni, E., & Calabrese, F. (2020). Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex. Nutrients, 12(2), 355. https://doi.org/10.3390/nu12020355
• Sbrini, G., Brivio, P., Sangiovanni, E., Fumagalli, M., Racagni, G., Dell’Agli, M., & Calabrese, F. (2020b). Chronic Treatment with a Phytosomal Preparation Containing Centella asiatica L. and Curcuma longa L. Affects Local Protein Synthesis by Modulating the BDNF-mTOR-S6 Pathway. Biomedicines, 8(12), 544. https://doi.org/10.3390/biomedicines8120544
• Semalty, A. (2014). Cyclodextrin and phospholipid complexation in solubility and dissolution enhancement: a critical and meta-analysis. Expert opinion on drug delivery, 11(8), 1255-1272. https://doi.org/10.1517/17425247.2014.916271
• Sgorlon, S., Colitti, M., Asquini, E., Ferrarini, A., Pallavicini, A., & Stefanon, B. (2012). Administration of botanicals with the diet regulates gene expression in peripheral blood cells of Sarda sheep during ACTH challenge. Domestic animal endocrinology, 43(3), 213–226. https://doi.org/10.1016/j.domaniend.2012.03.001
• Sharma, S., & Sahu, A. N. (2016). Development, Characterization, and Evaluation of Hepatoprotective Effect of Abutilon indicum and Piper longum Phytosomes. Pharmacognosy research, 8(1), 29–36. https://doi.org/10.4103/0974-8490.171102
• Shivanand, P., & Kinjal, P. (2010). Phytosomes: technical revolution in phytomedicine. International Journal of PharmTech Research, 2(1), 627-631.
• Singh, A., Saharan, V. A., Singh, M., & Bhandari, A. (2011). Phytosome: drug delivery system for polyphenolic phytoconstituents. Iranian Journal of Pharmaceutical Sciences, 7(4), 209-219.
• Singh, P., Singh, M., Kanoujia, J., Arya, M., Saraf, S. K., & Saraf, S. A. (2016). Process optimization and photostability of silymarin nanostructured lipid carriers: effect on UV-irradiated rat skin and SK-MEL 2 cell line. Drug delivery and translational research, 6(5), 597–609. https://doi.org/10.1007/s13346-016-0317-8
• Singh, R. P., & Narke, R. (2015). Preparation and evaluation of phytosome of lawsone. International Journal of Pharmaceutical Sciences and Research (IJPSR), 6(12), 5217-5226.
• Singh, R. P., Gangadharappa, H. V., & Mruthunjaya, K. (2018). Phytosome complexed with chitosan for gingerol delivery in the treatment of respiratory infection: In vitro and in vivo evaluation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 122, 214–229. https://doi.org/10.1016/j.ejps.2018.06.028
• Singh, R. P., Gangadharappa, H. V., & Mruthunjaya, K. (2018). Phytosome complexed with chitosan for gingerol delivery in the treatment of respiratory infection: In vitro and in vivo evaluation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 122, 214–229. https://doi.org/10.1016/j.ejps.2018.06.028
• Singh, R. P., Gu, M., & Agarwal, R. (2008). Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer research, 68(6), 2043–2050. https://doi.org/10.1158/0008-5472.CAN-07-6247
• Singh, R. P., Raina, K., Sharma, G., & Agarwal, R. (2008). Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clinical cancer research: an official journal of the American Association for Cancer Research, 14(23), 7773–7780. https://doi.org/10.1158/1078-0432.CCR-08-1309
• Smith, M. C., Crist, R. M., Clogston, J. D., & McNeil, S. E. (2017). Zeta potential: a case study of cationic, anionic, and neutral liposomes. Analytical and bioanalytical chemistry, 409(24), 5779-5787. https://doi.org/10.1007/s00216-017-0527-z
• Solda, C., Bardini, R., Sperti, C., Da Dalt, G., Gion, M., Fiduccia, P., … & Pastorelli, D. (2015). Phase II study of Gemcitabine and Curcumin (Meriva®) as first line treatment for locally advanced or metastatic pancreatic cancer: preliminary results. Annals of Oncology, 26, vi102. https://doi.org/10.1093/annonc/mdv344.41
• Solda, C., Sperti, C., Romeo, B., Da Dalt, G., Gion, M., Ursini, F., … & Pastorelli, D. (2016). Use of Meriva as complementary therapy of locally advanced or metastatic pancreatic cancer (PC) with gemcitabine (GEM). J Clin Oncol. 2016;34(15_suppl): e15696–e15696. doi:10.1200/JCO.2016.34.15_suppl.e15696204 
• Suriyakala, P. C., Babu, N. S., Rajan, D. S., & Prabakaran, L. (2014). Phospholipids as versatile polymer in drug delivery systems. Int J Pharm Pharm Sci, 6(1), 8-11. https://innovareacademics.in/journal/ijpps/Vol6Issue1/7714.pdf
• Tedesco, D., Tameni, M., Steidler, S., Galletti, S., & Di Pierro, F. (2003). Effect of silymarin and its phospholipid complex against AFM1 excretion in an organic dairy herd. Milchwissenschaft, 58(7-8), 416-419.
• Telange, D. R., Patil, A. T., Pethe, A. M., Fegade, H., Anand, S., & Dave, V. S. (2017). Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential. European Journal of Pharmaceutical Sciences, 108, 36-49. https://doi.org/10.1016/j.ejps.2016.12.009
• Telange, D. R., Patil, A. T., Pethe, A. M., Tatode, A. A., Anand, S., & Dave, V. S. (2016). Kaempferol-phospholipid complex: formulation, and evaluation of improved solubility, in vivo bioavailability, and antioxidant potential of kaempferol. Journal of excipients and food chemicals, 7(4), 1174.
• Teng, C. F., Yu, C. H., Chang, H. Y., Hsieh, W. C., Wu, T. H., Lin, J. H., Wu, H. C., Jeng, L. B., & Su, I. J. (2019). Chemopreventive Effect of Phytosomal Curcumin on Hepatitis B Virus-Related Hepatocellular Carcinoma in A Transgenic Mouse Model. Scientific reports, 9(1), 10338. https://doi.org/10.1038/s41598-019-46891-5
• Theoharides, T. C., Cholevas, C., Polyzoidis, K., & Politis, A. (2021). Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue. BioFactors (Oxford, England), 47(2), 232–241. https://doi.org/10.1002/biof.1726
• Tisato, V., Zauli, G., Rimondi, E., Gianesini, S., Brunelli, L., Menegatti, E., Zamboni, P., & Secchiero, P. (2013). Inhibitory effect of natural anti-inflammatory compounds on cytokines released by chronic venous disease patient-derived endothelial cells. Mediators of inflammation, 2013, 423407. https://doi.org/10.1155/2013/423407
• Togni, S., Maramaldi, G., Di Pierro, F., & Biondi, M. (2014). A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis. Clinical, cosmetic and investigational dermatology, 7, 321–327. https://doi.org/10.2147/CCID.S69240
• Tripathy, S., Patel, D. K., Barob, L., & Naira, S. K. (2013). A review on phytosomes, their characterization, advancement & potential for transdermal application. Journal of Drug Delivery and Therapeutics, 3(3), 147-152. https://doi.org/10.22270/jddt.v3i3.508
• Tsao, R. (2010). Chemistry and biochemistry of dietary polyphenols. Nutrients, 2(12), 1231-1246. https://doi.org/10.3390/nu2121231
• Tung, B. T., Hai, N. T., & Son, P. K. (2017). Hepatoprotective effect of Phytosome Curcumin against paracetamol-induced liver toxicity in mice. Brazilian Journal of Pharmaceutical Sciences, 53. https://doi.org/10.1590/s2175-97902017000116136
• Tuyaerts, S., Rombauts, K., Everaert, T., Van Nuffel, A., & Amant, F. (2019). A Phase 2 Study to Assess the Immunomodulatory Capacity of a Lecithin-based Delivery System of Curcumin in Endometrial Cancer. Frontiers in nutrition, 5, 138. https://doi.org/10.3389/fnut.2018.00138
• Ullah, F., Liang, H., Niedermayer, G., Münch, G., & Gyengesi, E. (2020). Evaluation of Phytosomal Curcumin as an Anti-inflammatory Agent for Chronic Glial Activation in the GFAP-IL6 Mouse Model. Frontiers in neuroscience, 14, 170. https://doi.org/10.3389/fnins.2020.00170
• Vigna, G. B., Costantini, F., Aldini, G., Carini, M., Catapano, A., Schena, F., Tangerini, A., Zanca, R., Bombardelli, E., Morazzoni, P., Mezzetti, A., Fellin, R., & Maffei Facino, R. (2003). Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism: clinical and experimental, 52(10), 1250–1257. https://doi.org/10.1016/s0026-0495(03)00192-6
• Williams, B., Watanabe, C. M., Schultz, P. G., Rimbach, G., & Krucker, T. (2004). Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability. Neurobiology of aging, 25(7), 955–962. https://doi.org/10.1016/j.neurobiolaging.2003.10.008
• Wright, A., Benjamin, S., & Ruggieri, R. (2017, June). Meriva and a novel chemically-modified curcumin for the treatment of medulloblastoma. In 4th Biennial Conference on Pediatric Neuro-Oncology Basic and Translational Research. https://doi.org/10.1093%2Fneuonc%2Fnox083.186
• Xu, L., Xu, D., Li, Z., Gao, Y., & Chen, H. (2019). Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells. Beilstein journal of nanotechnology, 10(1), 1933-1942. https://doi.org/10.3762/bjnano.10.189
• Yu, F., Li, Y., Chen, Q., He, Y., Wang, H., Yang, L., Guo, S., Meng, Z., Cui, J., Xue, M., & Chen, X. D. (2016). Monodisperse microparticles loaded with the self-assembled berberine-phospholipid complex-based phytosomes for improving oral bioavailability and enhancing hypoglycemic efficiency. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 103, 136–148. https://doi.org/10.1016/j.ejpb.2016.03.019
• Yu, F., Li, Y., Chen, Q., He, Y., Wang, H., Yang, L., Guo, S., Meng, Z., Cui, J., Xue, M., & Chen, X. D. (2016). Monodisperse microparticles loaded with the self-assembled berberine-phospholipid complex-based phytosomes for improving oral bioavailability and enhancing hypoglycemic efficiency. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 103, 136–148. https://doi.org/10.1016/j.ejpb.2016.03.019
• Yu, Z., Liu, X., Chen, H., & Zhu, L. (2020). Naringenin-Loaded Dipalmitoylphosphatidylcholine Phytosome Dry Powders for Inhaled Treatment of Acute Lung Injury. Journal of aerosol medicine and pulmonary drug delivery, 33(4), 194–204. https://doi.org/10.1089/jamp.2019.1569
• Yu, Z., Liu, X., Chen, H., & Zhu, L. (2020). Naringenin-Loaded Dipalmitoylphosphatidylcholine Phytosome Dry Powders for Inhaled Treatment of Acute Lung Injury. Journal of aerosol medicine and pulmonary drug delivery, 33(4), 194–204. https://doi.org/10.1089/jamp.2019.1569
• Zhang, D. W., Fu, M., Gao, S. H., & Liu, J. L. (2013). Curcumin and diabetes: a systematic review. Evidence-based complementary and alternative medicine : eCAM, 2013, 636053. https://doi.org/10.1155/2013/636053
• Zhao, X., Shi, C., Zhou, X., Lin, T., Gong, Y., Yin, M., … & Fang, J. (2019). Preparation of a nanoscale dihydromyricetin-phospholipid complex to improve the bioavailability: in vitro and in vivo evaluations. European Journal of Pharmaceutical Sciences, 138, 104994. https://doi.org/10.1016/j.ejps.2019.104994