Evaluation of Biochemical Changes of Benzo (A) Pyrene Induced Lung Carcinogenesis in Vivo and its Prevention by Vesicular Drug Targeting

Sunit Kumar Chakraborty
Department of Zoology, Raja Rammohun Roy Mahavidyalaya, Radhanagar, Nangulpara, Hooghly- 712406, West Bengal, India

DOI: https://doi.org/10.52756/lbsopf.2024.e01.013

Keywords: Benzo(a)pyrene, ROS, Biochemical changes, lung carcinogenesis, prevention by liposomal Curcumin

Abstract:
Lung cancer is the leading cause of cancer mortality world-wide. Cigarette smoking is the most established risk factor for lung carcinogenesis; however, the effects of benzo (a) pyrene [B(a)P], one of the key carcinogens in smoke, on the progression of lung cancer are obscure. The identification of key regulatory and molecular mechanisms involved in lung carcinogenesis is, therefore, critical to understanding this disease and could ultimately lead to targeted therapies to improve prevention and treatment. In an earlier study, I observed the effect of curcumin on the changes in the activities of endogenous antioxidants and lipohydroperoxide in rat lung injury by the administration of B(a)P. In the present study, I am interested in investigating whether B(a)P produces ROS, which activates inflammatory mediators and Wnt/β-catenin signaling to produce a lot of transcriptional genes and biochemical changes involved in lung carcinogenesis and its mechanistic prevention by the targeting of liposomal curcumin in rat.

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How to Cite
Sunit Kumar Chakraborty⃰ (2024). Evaluation of Biochemical Changes of Benzo (A) Pyrene Induced Lung Carcinogenesis in Vivo and its Prevention by Vesicular Drug Targeting. © International Academic Publishing House (IAPH), Dr. Somnath Das, Dr. Ashis Kumar Panigrahi, Dr. Rose Stiffin and Dr. Jayata Kumar Das (eds.), Life as Basic Science: An Overview and Prospects for the Future Volume: 1, pp. 165-171. ISBN: 978-81-969828-9-8 doi: https://doi.org/10.52756/ lbsopf.2024.e01.013

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