Exploration of The Therapeutic Effects of a Dietary Flavonoid Rutin

Sukanya Kundu
Department of Zoology, Diamond Harbour Women’s University, Sarisha, West Bengal-743368, India

Sunita Jhulki
Department of Zoology, Diamond Harbour Women’s University, Sarisha, West Bengal-743368, India

Aparajita Pal
Department of Zoology, Diamond Harbour Women’s University, Sarisha, West Bengal-743368, India

DOI: https://doi.org/10.52756/lbsopf.2024.e01.014

Keywords: Rutin, Anti-inflammatory, Anti-carcinogen, Oxidative stress, neurodegenerative disorders, autoimmune disease

Abstract:
Phytochemicals, which are also known as phytonutrients, are secondary metabolites and natural bioactive compounds found in a wide variety of plants. They are abundantly present in foods like fruits, nuts, vegetables, whole grains and even in various parts of plants. There are different kinds of phytochemicals, namely, carotenoids, isoprenoids, polyphenols, phytosterols, saponins, dietary fibres, polysaccharides etc. Rutin is one of a such kinds of flavonoids that are widely found in asparagus, buckwheat, apples, figs, tea etc. Researchers report many therapeutic properties of rutin. Rutin has been reported to have a beneficial role in controlling various diseases such as cancer, hypertension, arteriosclerosis, diabetes, anti-inflammatory, cardiac diseases and obesity. In this chapter, we demonstrate a comprehensive study of various therapeutics activities of rutin.

References:

• Allen, C. L., & Bayraktutan, U. (2009). Oxidative stress and its role in the pathogenesis of ischaemic stroke. World Stroke Organization International Journal of Stroke. 4: 461–470.
• Bee, B., Jat, R., & Ahmad, S. (2023). Fabrication of microspheres and characterization of antimicrobial and anti-inflammatory activity isolated fraction from total alcoholic extract of Cassia fistula (Linn.) in carrageenan-Type-IV induced inflammatory rats. Int. J. Exp. Res. Rev., 32, 246-259. https://doi.org/10.52756/ijerr.2023.v32.021
• Biswas, T., Behera, B. K., & Madhu, N.R. (2023). Technology in the Management of Type 1 and Type 2 Diabetes Mellitus: Recent Status and Future Prospects. 26 pages, Springer Nature Singapore Pte Ltd., Advances in Diabetes Research and Management. pp. 111–136. Online ISBN-978-981-19-0027-3. https://doi.org/10.1007/978-981-19-0027-3_6
• Briegera, K., Schiavonea, S., Miller Jr, F.J., Krause, K.H. (2012). Reactive oxygen species: from health to disease. Swiss Medical Weekly, 142: w 13659.
• Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., & Faller, P. (2018). Oxidative stress and the amyloid beta peptide in Alzheimer’s disease. Redox biology. 14: 450–464.
• Crack, P. J., & Taylo, J. M. (2005). Reactive oxygen species and the modulation of stroke. Free Radical Biology & Medicine. 38:1433-1444.
• Dey, S., & Guha, P. (2020). A brief review on cigarette induced cellular. Int. J. Exp. Res. Rev., 23, 18-26. https://doi.org/10.52756/ijerr.2020.v23.002
• Dong, R., Yu, B., Yan, S., Qiu, Z., Lei, J., Chen, C., Li, Y., & Cao, B. (2020). Analysis of Vitamin P Content and Inheritance Models in Eggplant. Horticultural Plant Journal. 6, (4): 240-246. https://doi.org/10.1016/j.hpj.2020.05.005.
• Dumon, M., & Beal, M.F. (2011). Neuroprotective strategies involving ROS in Alzheimer’s disease. Free Radical Biology and Medicine, 51:1014-1026.
• Enogieru, A. B., Haylett, W., Hiss, D. C., Bardien, S., & Ekpo, O. E. (2018). Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders. Oxidative Medicine and Cellular Longevity. 2018: 6241017. doi: 10.1155/2018/6241017.
• Farha, A. K., Gan, R. Y., Li, H. B., Wu, D. T., Atanasov, A. G., Khalid Gul, K., Zhang, J. R., Yang, Q. Q., & Corke, H. (2020). The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives. Critical Reviews in Food Science and Nutrition. 62(3): 832-859. DOI: 10.1080/10408398.2020.1829541.
• Ganeshpurkar, A., & Saluja, A. K. The Pharmacological Potential of Rutin. Saudi Pharmaceutical Journal. (2016). 25:149–164. https://dx.doi.org/10.1016/j.jsps.2016.04.025.
• Gegotek, A., Kawałko, P. R., & Skrzydlewska, E. (2017). Rutin as a mediator of lipid metabolism and cellular signaling pathways interactions in fibroblasts altered by UVA and UVB radiation. Oxidative Medicine and Cellular Longevity. 2017: 1-20: 4721352. doi: 10. 1155/2017/4721352.
• Ghosh, S., Nahar, N., Dasgupta, D., Sarkar, B., Biswas, P., Chakraborty, R., Acharya, C.K., Jana, S.K., & Madhu, N.R. (2022). Socioeconomic Disparity in Health of Rural Communities in the Himalayan Foothills: Mahananda Wildlife Sanctuary, West Bengal. Chettinad Health City Medical Journal.  11(2), 9-18. 
• Gula, A., Kunwarb, B., Mazhara, M., Faizib, S., Ahmedb, D., Shahb, M.R., Simjee, S.U. (2018). Rutin and rutin-conjugated gold nanoparticles ameliorate collagen-induced arthritis in rats through inhibition of NF-κB and iNOS activation. International Immunopharmacology. 59: 310–317.doi: https://doi.org/10.1016/j.intimp.2018.04.017.
• Haloi, R., Chanda, D., Hazarika, J., & Barman, A. (2023). Statistical feature-based EEG signals classification using ANN and SVM classifiers for Parkinson’s disease detection. Int. J. Exp. Res. Rev., 31(Spl Volume), 141-149. https://doi.org/10.52756/10.52756/ijerr.2023.v31spl.014
• Ibrahim, A. K., Youssef, A. I., Arafa, A. S., & Ahmed, S. A. (2013). AntiH5N1 virus flavonoids from Capparis sinaica Veill. Natural Product Research. 27 (22): 2149–2153.
• Imani, A., Maleki, N., Bohlouli, S., Kouhsoltani, M., Sharifi, S., & Dizaj, S. M. (2021). Molecular mechanisms of anticancer effect of rutin. Phytotherapy Research. 35(5):2500-2513. doi: 10.1002/ptr.6977.
• Kar, D., Ghosh, P., Suresh, P., Chandra, S., & Paul, D. (2022). Review on Phyto-chemistry & pharmacological activity of Melia azedarach. Int. J. Exp. Res. Rev., 28, 38-46. https://doi.org/10.52756/ijerr.2022.v28.006
• Lv, L., Yao, Y., Zhao, G., Zhu, G. (2018). Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model. Experimental and therapeutic medicine. 15: 506-512. doi: 10.3892/etm.2017.5365.
• Madhual, S., Nayak, D., Dalei, S., Padhi, T., & Das, N. R. (2023). Assessment of cardiovascular risk factors in male androgenetic alopecia: A case control study in a tertiary care hospital of western Odisha. Int. J. Exp. Res. Rev., 36, 425-432. https://doi.org/10.52756/ijerr.2023.v36.037
• Maeda, J., Roybal, E. J., Brents, C. A., Uesaka, M., Aizawa, Y., & Kato, T. A. (2014). Natural and glucosyl flavonoids inhibit poly (ADP-ribose) polymerase activity and induce synthetic lethality in BRCA mutant cells. Oncology Reports. 31(2): 551–556. doi: 10.3892/or.2013.2902.
• Mehta, V., Dey, A., Thakkar, N., Prabhakar, K., Jothimani G., & Banerjee, A. (2023). Anti-cancer Properties of Dietary Supplement CELNORM against Colon and Lung Cancer: An in vitro preliminary study. Int. J. Exp. Res. Rev., 32, 1-14. https://doi.org/10.52756/ijerr.2023.v32.001
• Moretti, E., Mazzi, L., Terzuoli, G., Bonechi, C., Iacoponi, F., Martini, S., Rossi, C., & Collodel, G. (2012). Effect of quercetin, rutin, naringenin and epicatechin on lipid peroxidation induced in human sperm. Reproductive Toxicology. 34 (4): 651–657.
• Negahdari, R., Bohlouli, S., Sharifi, S., Dizaj, S. M., Saadat, Y. R., S., Khezri, K., Jafari, S., Elham, A., Jahandizi, N. G., & Raeesi, S. (2021). Therapeutic benefits of rutin and its nanoformulations. Phytotherapy Research. 35(4):1719-1738. doi: 10.1002/ptr.6904.
• Pandey, P.; Rahman, M.; Bhatt, P.C.; Beg, S.; Paul, B.; Hafeez, A.; Al-Abbasi, F.A.; Nadeem, M.S.; Baothman, O.; & Anwar, F. (2018). Implication of nano-antioxidant therapy for treatment of hepatocellular carcinoma using PLGA nanoparticles of rutin. Nanomedicine. 13(8): 849–870. doi: 10.2217/nnm-2017-0306.
• Park, M. H., Kim, S., Song, Y. R., Kim, S., Kim, H. J., Na, H. S., & Chung, J. (2016). Rutin induces autophagy in cancer cells. International Journal of Oral Biology. 41(1): 45–51. doi: 10.11620/IJOB.2016.41.1. 045.
• Patel, K., & Patel, D. K. (2019) The Beneficial Role of Rutin, A Naturally Occurring Flavonoid in Health Promotion and Disease Prevention: A Systematic Review and Update. Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases. 2019: 457-479. https://doi.org/10.1016/B978-0-12-813820-5.00026-X.
• Pawar, S., Pawade, K., Nipate, S., Balap, A., Pimple, B., Wagh, V., Kachave, R., & Gaikwad, A. (2023). Preclinical evaluation of the diabetic wound healing activity of phytoconstituents extracted from Ficus racemosa Linn. leaves. Int. J. Exp. Res. Rev., 32, 365-377. https://doi.org/10.52756/ijerr.2023.v32.032
• Roy, R., Chakraborty, A., Jana, K., Sarkar, B., Biswas, P., & Madhu, N.R. (2023). The Broader Aspects of Treating Diabetes with the Application of Nanobiotechnology. Springer Nature Singapore Pte Ltd., Advances in Diabetes Research and Management, pp. 137–162, Online ISBN-978-981-19-0027-3, https://doi.org/10.1007/978-981-19-0027-3_7
• Sarkar, B., Biswas, P., Acharya, C.K., Ghorai, S.K., Nahar, N., Jana, S.K., Ghosh, S., Sarkar, D., Behera, B., & Madhu, N.R. (2021). Knowledge of Traditional Indian Medicinal Plants for the Management of COPD. Chettinad Health City Medical Journal.10(4), 184 –189.(P-ISSN: 2277-8845 & E-ISSN: 2278-2044). https://doi.org/10.36503/chcmj10(4)-05
• Sarkar, S., Sadhu, S., Roy, R., Tarafdar, S., Mukherjee, N., Sil, M., Goswami, A., & Madhu, N.R. (2023). Contemporary Drifts in Diabetes Management. Int. J. App. Pharm., 15(2), 1-9. https://doi.org/10.22159/ijap.2023v15i2.46792
• Satari, A., Ghasemi, S., Habtemariam, S., Asgharian, S., & Lorigooini, Z. (2021). Rutin: A Flavonoid as an Effective Sensitizer for Anticancer Therapy; Insights into Multifaceted Mechanisms and Applicability for Combination Therapy. Evidence-Based Complementary and Alternative Medicine. 2021:9913179. doi: 10.1155/2021/9913179.
• Selvaraj, G., Kaliamurthi, S., & Thiruganasambandam, R. (2016). Molecular docking studies of rutin on matrix metalloproteinase. Insights in Biomedicine. 1(1-4):1–5.
• Singh, H., & Sharma, D. (2023). Efficacy and Safety of Muscle Rub Ointment in The Management of Arthritis and Certain Musculoskeletal Disorders. Int. J. Exp. Res. Rev., 34(Special Vol.), 146-151. https://doi.org/10.52756/ijerr.2023.v34spl.014
• Sun, C.L., Jun, W., Bi, L. (2017). Rutin Attenuates Oxidative Stress and Proinflammatory Cytokine Level in Adjuvant Induced Rheumatoid Arthritis via Inhibition of NF-κB. Pharmacology. 100: 40–49. doi: 10.1159/000451027.
• Sur, T., Das, A., Bashar, S., Tarafdar, S., Sarkar, B., & Madhu, N.R. (2023). Biochemical Assay for Measuring Diabetes Mellitus. Springer Nature Singapore Pte Ltd., Advances in Diabetes Research and Management, pp. 1–20, Online ISBN-978-981-19-0027-3, https://doi.org/10.1007/978-981-19-0027-3_1
• Thangavel, M., Gopi, J., & Balakrishnan, D. (2023). Protection of hydrogen peroxide and Metal induced DNA damage by flavonoids. Int. J. Exp. Res. Rev., 32, 408-421. https://doi.org/10.52756/ijerr.2023.v32.036
• Thangavel, M., Gopi, J., & Balakrishnan, D. (2023). Protection of hydrogen peroxide and Metal induced DNA damage by flavonoids. Int. J. Exp. Res. Rev., 32, 408-421. https://doi.org/10.52756/ijerr.2023.v32.036
• Weng, M., Xie, X., Liu, C., Lim, K. L., Zhang, C. W., & Li, L. (2018). The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson ’s disease.          Parkinson ’s disease, 2018: 9163040. doi: 10.1155/2018/9163040.

How to Cite
Sukanya Kundu, Sunita Jhulki and Aparajita Pal (2024). Exploration of The Therapeutic Effects of a Dietary Flavonoid Rutin. © International Academic Publishing House (IAPH), Dr. Somnath Das, Dr. Ashis Kumar Panigrahi, Dr. Rose Stiffin and Dr. Jayata Kumar Das (eds.), Life as Basic Science: An Overview and Prospects for the Future Volume: 1, pp. 172-184. ISBN: 978-81-969828-9-8 doi: https://doi.org/10.52756/lbsopf.2024.e01.014

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