Unveiling the Potentials of Withania somnifera (L.) Dunal as a Precise Therapeutic Intervention Against Glioblastoma Multiforme

Sohini Kulavi
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, West Bengal, NH-12 (Old NH-34), Simhat, Haringhata, Nadia, West Bengal, India

Debajit Dhar
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, West Bengal, NH-12 (Old NH-34), Simhat, Haringhata, Nadia, West Bengal, India

Karan Iyer
Sustainable Agriculture Division, The Energy & Resources Institute, TERI Gram, Gurugram Faridabad road, Gwal Pahari, Gurugram, Haryana 122001, India

Arnab Kumar Ghosh
Department of Applied Biology, Maulana Abul Kalam Azad University of Technology, West Bengal, NH- 12 (Old NH-34) Simhat, Haringhata, Nadia 741249, West Bengal, India

Jaya Bandyopadhyay
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, West Bengal, NH-12 (Old NH34), Simhat, Haringhata, Nadia, West Bengal, India

DOI: https://doi.org/10.52756/lbsopf.2024.e01.007

Keywords: Glioblastoma Multiforme, Withania somnifera, phytotherapy, Withaferin A, Withanolides

Abstract:
Glioblastoma multiforme (GBM) is the most severe and fatal form of brain tumor, leading to a poor survival rate in patients and making a significant contribution to cancer-related deaths. The typical approaches to treating GBM involve surgical procedures followed by chemotherapy, targeting molecular pathways involving receptors like Epidermal Growth Factor Receptor (EGFR, EGFRvIII) and Vascular Endothelial Growth Factor Receptor (VEGFR) to modulate various cell signaling pathways. However, the effectiveness of current GBM treatments is notably constrained. Withania somnifera (WS) (L.) Dunal, commonly known as Ashwagandha, has a history spanning over 3,000 years in Ayurvedic and traditional medicine. This medicinal plant has diverse properties, encompassing anti-inflammatory, anticancer and antioxidant attributes. Recent advancements in the field of herbal and traditional medicines have explored its potential in managing deadly diseases like cancer. Ashwagandha or W. somnifera, mostly found in dry, sub-tropical regions of the world including India, is a well-known source of traditional and herbal medicines, and has many specific phytochemicals, viz. Withaferin A, Withanolide etc. This review discusses the potential of W. somnifera, supported by several research reports dealing with the extracts and phytochemicals from different parts of the plant, showing effectiveness against

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How to Cite
Sohini Kulavi, Debajit Dhar, Karan Iyer, Arnab Kumar Ghosh and Jaya Bandyopadhyay* (2024). Unveiling the Potentials of Withania somnifera (L.) Dunal as a Precise Therapeutic Intervention Against Glioblastoma Multiforme. © International Academic Publishing House (IAPH), Dr. Somnath Das, Dr. Ashis Kumar Panigrahi, Dr. Rose Stiffin and Dr. Jayata Kumar Das (eds.), Life as Basic Science: An Overview and Prospects for the Future Volume: 1, pp. 68-91. ISBN: 978-81-969828-9-8 doi: https://doi.org/10.52756/lbsopf.2024.e01.007

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